ABSTRACT
<p><b>OBJECTIVE</b>To summarize the clinical and pathological features of Gilbert syndrome.</p><p><b>METHODS</b>The clinical features and liver histological findings of 16 cases of Gilbert syndrome were reviewed.</p><p><b>RESULTS</b>Of the 16 cases (13 males and 3 females, with an age range from 14 to 40 years), all had recurrent jaundice, unconjugated hyperbilirubinemia and lipofuscin granules in the hepatocytes around the hepatic perivenular areas. The genetic analysis of the two patients showed that the site of genetic mutations were located at exon 1 (Gly71Arg).</p><p><b>CONCLUSIONS</b>The diagnosis of Gilbert disease can be improved by combining the data of clinical features, the genetic analysis findings and the histological changes of the livers of the patients.</p>
Subject(s)
Adolescent , Adult , Female , Humans , Male , Young Adult , Gilbert Disease , Genetics , Pathology , Liver , PathologyABSTRACT
<p><b>OBJECTIVE</b>To study the histopathological changes of livers in idiopathic portal hypertension (IPH).</p><p><b>METHODS</b>Liver specimens from 29 cases with idiopathic portal hypertension were studied. Histological preparations of the livers were stained with haematoxylin eosin and Masson's trichrome; reticular fibers in the liver tissues were demonstrated. The slides were also stained using some immunohistochemistry methods, and the pathological changes of the livers were analyzed.</p><p><b>RESULTS</b>The characteristic changes found in these IPH livers were dense portal fibrosis; obliteration, with or without phlebitis, of the branches of the portal vein; dilatation of the sinusoids; atrophy and nodular hyperplasia of liver cells.</p><p><b>CONCLUSIONS</b>Histopathological changes of the livers in IPH are dense portal fibrosis, portal vein branch obliteration and nodular hyperplasia of liver cells. These are the main features for a histopathological diagnosis of IPH.</p>
Subject(s)
Adolescent , Adult , Female , Humans , Male , Middle Aged , Young Adult , Fibrosis , Pathology , Hypertension, Portal , Pathology , Liver , PathologyABSTRACT
Aim The release process of an anticancer agent, DOX_HAP in rabbit liver was observed.Methods DOX and DOX_HAP were separately injectoed into rabbit livers under the guide of B type ultrasound. Dox concentrations in plasma and liver tissue of the rabbits in both groups were measured by fluorescent stectrophotometer and compared. Results The concentration of complex could existed in the liver tissue about 5 d(1 000 ng?g-1) when it was given in a dose of 2 mg?g-1. At the 10 min the concentration in plasma would be reduced about 1/2 as compared with that in the control group. Conclusions The DOX_ HAP complex not only could increase and insist in an effective concentration of DOX at the local injecting area of liver tissue, but also reduce its concerntration in the plasma. Therefore, it could decrease the toxicity and side_effect of DOX.